Computational Molecular Biology, aka Algorithms for Computational Biology
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ODE Module Guide
Useful papers
Rosenfeld N, Elowitz MB, Alon U. Negative autoregulation speeds the response times of transcription networks J Mol Biol. 2002 Nov 8;323(5):785-93.
Mangan, S., and Alon, U. (2003). Structure and function of the feed-forward loop network motif. Proc Natl Acad Sci U S A 100, 11980-11985.
Mangan S, Zaslaver A, Alon U.The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks.J Mol Biol. (2003) 334:197-204.
Mangan S, Itzkovitz S, Zaslaver A, Alon U. The incoherent feed-forward loop accelerates the response-time of the gal system of Escheri chia coli. J Mol Biol. (2006) 356:1073-81.
Wednesday, November 4
Notes part 1
,
Notes part 2
Due Friday, November 6:
Homework 1
By Monday, November 9:
Set up Matlab!
Wednesday, November 11
Notes part 3
Due Friday, November 13:
Homework 2
Friday, November 13
Notes part 4
Due Friday, November 20:
Programming Homework 1
Monday, November 16
Notes part 5
Before next class:
Paper by
Goutsias and Kim
, paper by
Goutsias and Lee
Wednesday, November 18
Before next class:
Read at least the Introduction and Materials and Methods sections from
Chen et al
Read
Kuttykrishnan et al
, skipping the Results and Discussion sections, if necessary
Bring to class a written list of questions/comments to discuss and turn them in after class
Friday, November 20
Discussion of Chen et al and Kuttykrishnan et al approaches to modeling regulatory networks using ODEs